Insulin autoimmune syndrome

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Synonyms: Hirata disease

A rare endocrine disease characterized by hyperinsulinemic hypoglycemia associated with the presence of autoantibodies to endogenous insulin without previous exposure to exogenous insulin. Patients usually present in adulthood with postprandial fasting- or exercise-induced hypoglycemia often with pronounced neuroglycopenic symptoms. Laboratory investigations reveal markedly elevated serum insulin as well as increased C-peptide and proinsulin. The condition may be associated with other autoimmune diseases monoclonal gammopathy and/or recent exposure to certain medications.

Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview. Reference: Access aggregated data from Orphanet at Orphadata. Orphadata: Free access data from Orphanet. © INSERM 1999. Available on Data version July 2024

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Clinical Trials

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