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Synonyms: CDG syndrome type IIb | CDG-IIb | CDG2B | Carbohydrate deficient glycoprotein syndrome type IIb | Congenital disorder of glycosylation type 2b | Congenital disorder of glycosylation type IIb | Glucosidase 1 deficiency

MOGS-CDG is a form of congenital disorders of N-linked glycosylation characterized by generalized hypotonia craniofacial dysmorphism (prominent occiput short palpebral fissures long eyelashes broad nose high arched palate retrognathia) hypoplastic genitalia seizures feeding difficulties hypoventilation severe hypogammaglobulinemia with generalized edema and increased resistance to particular viral infections (particularly to enveloped viruses). The disease is caused by loss-of-function mutations in the gene MOGS (2p13.1).

Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview.

Reference: Access aggregated data from Orphanet at Orphadata.

Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http: // Data version October 2023.

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Advocacy Organizations

Portuguese Association for CDG

The APCDG aims to holistically support families affected by a CDG. Our mission based on the pillars of disease awareness, education, research and to subsequently, speed up the development of therapies that will significantly benefit patients and their family members. We believe that only by adopting a patient-centric approach we will find ways to improve their quality of life.


Our mission is to promote greater awareness and understanding of CDG & NGLY1-Deficiency, to provide information and support to families affected by CDG & NGLY1, and to advocate for and fund scientific research to advance the diagnosis and treatment of CDG & NGLY1-Deficiency.

Mississippi Metabolics Foundation

Mississippi Metabolics Foundation (MMF) was founded to raise awareness, educate, and provide support to those living or caring for someone with genetic metabolic disorders/inborn errors of metabolism (IEM).

Clinical Trials

For a list of clinical trials in this disease area, please click here.