Myeloid/lymphoid neoplasm associated with PDGFRB rearrangement

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Myeloid/lymphoid neoplasm associated with PDGFRB rearrangement

A rare malignant neoplastic disease characterized by clonal proliferation of myeloid and/or lymphoid precursors harboring rearrangements in the PDGFRB gene in the blood bone marrow and often other tissues as well (spleen lymph nodes skin etc.). It usually presents as chronic myelomonocytic leukemia with eosinophilia chronic eosinophilic leukemia atypical chronic myelogenous leukemia juvenile myelomonocytic leukemia myelodysplastic syndrome acute myeloid leukemia or acute lymphoblastic leukemia. Patients usually present with anemia leukocytosis monocytosis eosinophilia and/or splenomegaly or systemic symptoms such as fever sweating and/or weight loss.

Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview.

Reference: Access aggregated data from Orphanet at Orphadata.

Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http://www.orphadata.org. Data version March 2024

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