Non-progressive predominantly posterior cavitating leukoencephalopathy with peripheral neuropathy

Get in touch with RARE Concierge.

Contact RARE Concierge

Non-progressive predominantly posterior cavitating leukoencephalopathy with peripheral neuropathy

A rare mitochondrial disease characterized by a distinctive MRI pattern of cavitating leukodystrophy predominantly in the posterior region of the cerebral hemispheres. The clinical picture varies widely between acute neurometabolic decompensation in infancy with loss of developmental milestones seizures and pyramidal signs rapidly evolving into spastic tetraparesis to subtle neurological symptoms presenting in adolescence. The disease course tends to stabilize over time in most patients and marked recovery of milestones may be observed.

Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview.

Reference: Access aggregated data from Orphanet at Orphadata.

Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http://www.orphadata.org. Data version March 2024

Newly diagnosed with
Non-progressive predominantly posterior cavitating leukoencephalopathy with peripheral neuropathy?

Our RARE Concierge Services Guides are available to assist you by providing information, resources and connections as you navigate your rare disease journey.

Get Concierge Help

Clinical Trials

For a list of clinical trials in this disease area, please click here.