Primary membranoproliferative glomerulonephritis

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Primary membranoproliferative glomerulonephritis

Synonyms: Mesangiocapillary glomerulonephritis | Primary MPGN

A rare glomerular disease characterized by a pattern of glomerular injury on kidney biopsy with characteristic light microscopic changes: mesangial hypercellularity endocapillary proliferation and thickening of the glomerular basement membrane (GBM). On the basis of immunofluorescence (IF) the disorder is divided into C3 glomerulopathy (C3G) or immunoglobulin-mediated membranoproliferative glomerulonephritis. Through electron microscopy C3G is further divided into Dense deposit disease with highly electrondense deposits in the glomerular basement membrane and C3 glomerulonephritis with mesangial intramembranous subendothelial and subepithelial deposits. Secondary causes (autoimmune infectious malignancies) are excluded.

Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview.

Reference: Access aggregated data from Orphanet at Orphadata.

Orphadata: Free access data from Orphanet. © INSERM 1999. Available on Data version December 2023

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