Insulin autoimmune syndrome
Synonyms: Hirata disease
A rare endocrine disease characterized by hyperinsulinemic hypoglycemia associated with the presence of autoantibodies to endogenous insulin without previous exposure to exogenous insulin. Patients usually present in adulthood with postprandial fasting- or exercise-induced hypoglycemia often with pronounced neuroglycopenic symptoms. Laboratory investigations reveal markedly elevated serum insulin as well as increased C-peptide and proinsulin. The condition may be associated with other autoimmune diseases monoclonal gammopathy and/or recent exposure to certain medications.
Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview.
Reference: Access aggregated data from Orphanet at Orphadata.
Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http://www.orphadata.org. Data version April 2024
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